Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus

Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus.

Patients with systemic lupus erythematosus (SLE) often develop glomerulonephritis (i.e., inflammation in the glomeruli of the kidney), commonly referred to as lupus nephritis. Patients with lupus nephritis typically have autoantibodies to the complement classical pathway protein C1q. Whether these anti-C1q antibodies play any role in the development of lupus nephritis has been unclear. In this ...

Autoantibodies against C1q in systemic lupus erythematosus.

Anti-C1q antibodies in systemic lupus erythematosus.

OBJECTIVE Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and othe...

ANTINEUTROPHIL CY TOPLASMIC AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

Antineutrophil cytoplasmic autoantibodies (ANCA) were first described in patients with necrotizing glomerulonephritis. The original observation passed unnoticed until an association was made between ANCA and active Wegener's granulomatosis. Since then, tremendous progress has been made in elucidating the association between ANCA subtypes and clinicopathologic syndromes, and the potential p...

Autoantibodies against C1q: view on association between systemic lupus erythematosus disease manifestation and C1q autoantibodies.

_______________________________ Correspondence to: Daniela Monova, 24 Veliko Turnovo str, Sofia 1504, Bulgaria, tel++3598437705 e-mail: [email protected] Autoantibodies Against C1q: View on Association Between Systemic Lupus Erythematosus Disease Manifestation and C1q autoantibodies D. Monova, S. Monov, K. Rosenova, T. Argirova Medical University Sofia, Department of Internal Medicine, Sofia ...